From actinic keratosis to squamous cell carcinoma.

  title={From actinic keratosis to squamous cell carcinoma.},
  author={Jean-paul Ortonne},
  journal={The British journal of dermatology},
  volume={146 Suppl 61},
The development of actinic keratosis (AK) and squamous cell carcinoma (SCC) is the result of a complex sequence of events initiated by exposure to ultraviolet (UV) light. The application of sunscreens prior to sun exposure has been reported to reduce the incidence of AK. The initial damage takes place in the DNA and most of the UV-induced lesions in the DNA are repaired. However, mutations may occur as a result of base mispairing of the cell and its DNA replicate before the DNA lesion is… CONTINUE READING

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