From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning.

@article{Tyler2002FromAT,
  title={From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning.},
  author={William J. Tyler and Mariana Mac{\'i}as Alonso and Clive R. Bramham and Lucas Pozzo-Miller},
  journal={Learning \& memory},
  year={2002},
  volume={9 5},
  pages={
          224-37
        }
}
One of the most rigorously investigated problems in modern neuroscience is to decipher the mechanisms by which experience-induced changes in the central nervous system are translated into behavioral acquisition, consolidation, retention, and subsequent recall of information. Brain-derived neurotrophic factor (BDNF) has recently emerged as one of the most potent molecular mediators of not only central synaptic plasticity, but also behavioral interactions between an organism and its environment… 

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References

SHOWING 1-10 OF 169 REFERENCES
Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors.
TLDR
A role for BDNF in the modulation of synaptic transmission in the hippocampus is suggested through a previously unreported mechanism--increased postsynaptic responsiveness via a phosphorylation-dependent pathway.
Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus
TLDR
The results suggest that BDNF may regulate LTP in developing and adult hippocampus by enhancing synaptic responses to tetanic stimulation, and a TrkB–IgG fusion protein, which scavenges endogenous BDNF11, reduced the synaptic responses in adult hippocampus as well as the magnitude of LTP.
Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-D-aspartate receptor subunit 1.
  • P. Suen, K. Wu, I. Black
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
TLDR
It is reported that BDNF, within 5 min of exposure, elicits a dose-dependent increase in phosphorylation of the N-methyl-D-aspartate receptor subunit 1, suggesting a potential mechanism for trophin-induced potentiation of synaptic transmission.
Essential Role for TrkB Receptors in Hippocampus-Mediated Learning
Involvement of Brain-Derived Neurotrophic Factor in Spatial Memory Formation and Maintenance in a Radial Arm Maze Test in Rats
TLDR
The results suggest that BDNF plays an important role not only in the formation, but also in the retention and/or recall, of spatial memory.
Trophic regulation of synaptic plasticity.
  • I. Black
  • Biology
    Journal of neurobiology
  • 1999
TLDR
A model is proposed in which activity-driven experience activates specific BDNF gene promoters, leading to enhanced transcription, elevated trophin levels, postsynaptic NMDA receptor activation and increased synaptic transmission, which may contribute to enhanced long-term potentiation, a correlate of learning and memory.
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
TLDR
It is suggested that BDNF might have a functional role in the expression of LTP in the hippocampus, and the magnitude of the potentiation, as well as the percentage of cases in which LTP could be induced successfully, was clearly affected.
...
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