From T-tubule to sarcolemma: damage-induced dysferlin translocation in early myogenesis.

@article{Klinge2007FromTT,
  title={From T-tubule to sarcolemma: damage-induced dysferlin translocation in early myogenesis.},
  author={Lars Klinge and Steve H. Laval and Sharon M. Keers and F. Duncan M. Haldane and Volker Straub and Rita Barresi and Katharine M. D. Bushby},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 8},
  pages={1768-76}
}
The dysferlin gene is mutated in limb-girdle muscular dystrophy type 2B, Miyoshi myopathy, and distal anterior compartment myopathy. In mature skeletal muscle, dysferlin is located predominantly at the sarcolemma, where it plays a role in membrane fusion and repair. To investigate the role of dysferlin during early muscle differentiation, its localization was studied at high resolution in a muscle cell line. This demonstrated that dysferlin is not expressed at the plasmalemma of myotubes but… CONTINUE READING

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