From Research Subgroup to Clinical Syndrome: Modifying the PANDAS Criteria to Describe PANS (Pediatric Acute-onset Neuropsychiatric

@article{Swedo2012FromRS,
  title={From Research Subgroup to Clinical Syndrome: Modifying the PANDAS Criteria to Describe PANS (Pediatric Acute-onset Neuropsychiatric},
  author={Elizabeth A Swedo and James Frederick Leckman and Noel R. Rose},
  journal={Pediatrics \& Therapeutics},
  year={2012},
  volume={2},
  pages={1-8}
}
Despite continued debates about the role of Group A streptococcal infections in the etiopathogenesis of PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections), experts on both sides of the controversy agree that a subgroup of children with obsessive-compulsive disorder (OCD) have an unusually abrupt onset of symptoms, accompanied by a variety of comparably severe and acute neuropsychiatric symptoms. The acuity of symptom onset is the hallmark feature… Expand
Diagnostic Approach to Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (PANDAS): A Narrative Review of Literature Data
TLDR
A test panel is proposed to support clinicians in the workout of PANDAS/PANS patients establishing an appropriate treatment and further studies are needed to improve knowledge on these acute-onset neuropsychiatric conditions. Expand
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TLDR
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TLDR
The available evidence does not convincingly support the concept that PANDAS are a well-defined, isolated clinical entity subdued by definite pathophysiological mechanisms; larger, prospective studies are necessary to reshape the nosography and disease mechanisms of post-streptococcal acute neuropsychiatric disorders other than SC. Expand
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TLDR
A positive effect of acute and prophylactic antibiotic-, psychiatric- and immunomodulating treatment, according to parental reports is shown. Expand
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TLDR
In fact, irritability, aggressivity, and food restriction were significantly more frequent in children with PANS and the levels of anti-streptolysin O and anti-DNAse B were higher in PANDAS. Expand
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TLDR
Although difficulties in documenting an association between Group A streptococcal infections and symptom onset/exacerbations may preclude a diagnosis of PANDAS in some children with acute-onset OCD, they do appear to meet criteria for pediatric acute-ONSet neuropsychiatric syndrome (PANS). Expand
Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part III—Treatment and Prevention of Infections
TLDR
A consensus management guideline for the infection components of PANS and its subset, pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection, is presented, to provide a set of practical guidelines. Expand
Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome : Part III — Treatment and Prevention of Infections
Objectives: Pediatric acute-onset neuropsychiatric syndrome (PANS) and its subset, pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS), are emergingExpand
No Cases of PANDAS on Follow-Up of Patients Referred to a Pediatric Movement Disorders Clinic
TLDR
The results support the notion that PANDAS, if it exists, is an exceedingly rare diagnosis encountered in a pediatric movement disorder clinic and indicate that PANS may be a more appropriate diagnosis. Expand
PANDAS/PANS in childhood: Controversies and evidence.
TLDR
Current working definitions of PANDAS/PANS are reviewed, published evidence for interventions related to this entity is discussed, and a clinical approach to children presenting with acute symptoms satisfying criteria for PANDas/Pans is proposed. Expand
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