From Receptor Balance to Rational Glucocorticoid Therapy

  title={From Receptor Balance to Rational Glucocorticoid Therapy},
  author={E. Ron de Kloet},
  • E. Ron de Kloet
  • Published 2014
Corticosteroids secreted as end product of the hypothalamic-pituitary-adrenal axis act like a double-edged sword in the brain. The hormones coordinate appraisal processes and decision making during the initial phase of a stressful experience and promote subsequently cognitive performance underlying the management of stress adaptation. This action exerted by the steroids on the initiation and termination of the stress response is mediated by 2 related receptor systems: mineralocorticoid… CONTINUE READING