From Pluripotent Stem Cells to Multifunctional Cordocytic Phenotypes in the Human Brain: An Ultrastructural Study

  title={From Pluripotent Stem Cells to Multifunctional Cordocytic Phenotypes in the Human Brain: An Ultrastructural Study},
  author={Viorel Pais and Leon Dănăilă and E. Pais},
  journal={Ultrastructural Pathology},
  pages={252 - 259}
Light microscopy and transmission electron microscopy were used to investigate surgical cases in a variety of pathological conditions (thromboses, tumors, cerebrovascular malformations, Moyamoya disease) to identify and characterize different phenotypes belonging to a new interstitial cell recently described ultrastructurally in the brain and here named “cordocyte.” Also, this work is an attempt to identify and characterize precursor/stem cells for cordocytic lineage in the perivascular areas… 
From Precursor/Stem Cells To Cordocytic Phenotypes In The Skin
A promissing cell for both fundamental knowledge and clinical applications – as a good candidate for transplantation in regenerative medicine – is a special interstitial cell described in the last few years with the terms: “Cajal-like cell,’ “telocyte,” or “cordocyte” in diverse extra-digestive organs.
Ultrastructural Characterization of a Developing Pericytic Microtumor in the White Matter Post Laceration
This is the first study concerning ultrastructural description of a tumoral mass into white matter post laceration with pericytic abnormal proliferation in primary central nervous system hemangiopericytoma.
Cordocytes-Stem Cells Cooperation in the Human Brain with Emphasis on Pivotal Role of Cordocytes in Perivascular Areas of Broken and Thrombosed Vessels
This is the first cytohistopathological study which illustrates and explains some facets of cordocytes-stem cells cooperation around the vessels of human brain with emphasis on the fundamental role of Cordocytes in response to vascular injuries.
Intercellular Communication by Extracellular Vesicles with Emphasis on the Roles of Cordocytes in the Human Brain. An Ultrastructural Study
This first study showed clearly that EVs can be important modulators of cell functions with roles in cell activation, differentiation, phenotypic change, cancer progression, from precursor/stem cells to tumoral phenotypes, because EVs are released en masse during key interactions and certain moments.
Epigenetic aspects of telocytes/cordocytes: jacks of all trades, masters of most
It is proposed that T/Cs are capable of forming an extensive intercellular information transmission and executive system that may utilize electric currents, small molecules, exosomes and possibly electrical events within the cytoskeleton—to modulate homeostasis, stem cell activity, tissue repair, peristalsis, anticancer activity, and other complex functions in many organs.


The primary cilium of telocytes in the vasculature: electron microscope imaging
The presence of telocytes located on the extracellular matrix of blood vessels (arterioles, venules and capillaries) is shown by immunohistochemistry and transmission electron microscopy and the first evidence of a primary cilium in telocytes is demonstrated.
Stereological Analysis on Migration of Human Neural Stem Cells in the Brain of Rats Bearing Glioma
It is identified for the first time the rate and pattern of NSC migration to the tumor mass in vivo, which may provide useful information with respect to preclinical research of gene therapy for malignant gliomas.
Interstitial Cells of Blood Vessels
This review summarises the knowledge of the functional and structural properties of vascular interstitial cells accumulated so far, offers hypotheses on their physiological role, and proposes directions for future research.
Subset of cells immunopositive for neurokinin-1 receptor identified as arterial interstitial cells of Cajal in human large arteries
Systematic electron-microscopic analysis revealed that the cells displaying the features typical of interstitial cells of Cajal were a basic element of the human arterial wall architectonics.
The thread-protective cell, a new cell performing multiple tasks.
It is discovered that the pia mater is made up of such protective cells, which also play a role in preventing the neuroblasts from migrating, at the level of the corona radiata, double cortex and other neuronal migration disorders which may generate epilepsy.
Physiology, injury, and recovery of interstitial cells of Cajal: basic and clinical science.
Significant steps forward have been made in the understanding of the physiology of ICC as well as mechanisms of injury and recovery, which are the focus of this review.
The human trigeminal ganglion: c-kit positive neurons and interstitial cells.
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    Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
  • 2011
Biophysically Based Modeling of the Interstitial Cells of Cajal: Current Status and Future Perspectives
This review is focused on the cellular electrophysiology of ICC, examining several potential clinical applications of biophysically based ICC modeling from the subcellular through to the organ level, including ion channelopathies and ICC network degradation.
Biophysical based modeling of the interstitial cells of Cajal: current status and future perspectives
  • Front Physiol
  • 2011