From Pauling's abzyme concept to the new era of hydrolytic anti-DNA autoantibodies: a link to rational vaccine design? - A review

Abstract

Specific entities of naturally-occurring DNA hydrolytic/cytotoxic antibodies (abzymes) are linked to autoimmune and lymphoproliferative disorders. Suggested sequence of underlying activities conform to such entities penetrating the living cells, trans-locating to nucleus and recognising specific binding sites within single- or double-stranded DNA. Their origin is unknown since corresponding immunogens are unidentified. These anti-DNA antibodies could be the organism's immune response to microbial attack. Their structure, function and pathogenicity were investigated in wet-lab and via bioinformatics in context of Rational Vaccine Designs. This paper offers a comprehensive critical review on the subject in the light of known and newly proposed concepts.

DOI: 10.1504/IJBRA.2011.041735

Cite this paper

@article{Pavlovic2011FromPA, title={From Pauling's abzyme concept to the new era of hydrolytic anti-DNA autoantibodies: a link to rational vaccine design? - A review}, author={Mirjana Pavlovic and Michelle Cavallo and Anna Kats and Alex Kotlarchyk and Hanqi Zhuang and Yehuda Shoenfeld}, journal={International journal of bioinformatics research and applications}, year={2011}, volume={7 3}, pages={220-38} }