From Pan to pandemic

@article{Weiss1999FromPT,
  title={From Pan to pandemic},
  author={Robin A. Weiss and Richard W. Wrangham},
  journal={Nature},
  year={1999},
  volume={397},
  pages={385-386}
}
Further evidence that HIV-1 originally came from chimpanzees bears on a variety of issues — the evolution of AIDS viruses, disease transmission from animals to humans, and chimpanzee conservation and welfare. 

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References

SHOWING 1-10 OF 17 REFERENCES
Transgenic pigs and virus adaptation
Pigs offer the best hope of providing organs for transplantation to humans. But, in overcoming the problems of tissue rejection, we may be increasing our risk of infection from pig viruses.
An African HIV-1 sequence from 1959 and implications for the origin of the epidemic
TLDR
Multiple phylogenetic analyses not only authenticate this case as the oldest known HIV-1 infection, but also place its viral sequence near the ancestral node of subtypes B and D in the major group, indicating that these HIV- 1 subtypes, and perhaps all major-group viruses, may have evolved from a single introduction into the African population not long before 1959.
Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes
TLDR
The genome of a new SIVcpz strain is sequenced and the subspecies identity of all known SIV cpz-infected chimpanzees is determined, by mitochondrial DNA analysis, and it is found that two chimpanzee subspecies in Africa harbour SIVCPz and that their respective viruses form two highly divergent (but subspecies-specific) phylogenetic lineages.
Human infection by genetically diverse SIVSM-related HIV-2 in West Africa
TLDR
It is indicated that HIV-2, SIVSM and SIVMAC comprise a single, highly diverse group of lentiviruses which cannot be separated into distinct phylogenetic lineages according to species of origin.
Virology
NIAD supports a broad spectrum of both basic and applied research in virology to expand the understanding of the biology, pathogenesis, and the immunology of viral diseases, leading to their
J. Virol
  • J. Virol
  • 1998
Nature Med
  • Nature Med
  • 1998
Nature Med
  • Nature Med
  • 1998
J. Virol
  • J. Virol
  • 1997
J. Med. Primatol
  • J. Med. Primatol
  • 1996
...
1
2
...