From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map.

@article{Reymond2001FromPA,
  title={From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map.},
  author={Alexandre Reymond and Marc Friedli and Charlotte N. Henrichsen and F Chapot and Samuel Deutsch and Catherine Ucla and Colette Rossier and Robert Lyle and Michel Guipponi and Stylianos E. Antonarakis},
  journal={Genomics},
  year={2001},
  volume={78 1-2},
  pages={46-54}
}
A supernumerary copy of human chromosome 21 (HC21) causes Down syndrome. To understand the molecular pathogenesis of Down syndrome, it is necessary to identify all HC21 genes. The first annotation of the sequence of 21q confirmed 127 genes, and predicted an additional 98 previously unknown "anonymous" genes (predictions (PREDs) and open reading frames (C21orfs)), which were foreseen by exon prediction programs and/or spliced expressed sequence tags. These putative gene models still need to be… CONTINUE READING

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