From Na+/K+-ATPase and cardiac glycosides to cytotoxicity and cancer treatment.

  title={From Na+/K+-ATPase and cardiac glycosides to cytotoxicity and cancer treatment.},
  author={Petr Babula and Michal Masař{\'i}k and Vojtěch Adam and Ivo Provazn{\'i}k and Ren{\'e} Kizek},
  journal={Anti-cancer agents in medicinal chemistry},
  volume={13 7},
The cardiac glycosides are a group of compounds isolated from plants and some animals. They have been used in therapy for heart failure for many years. The cytotoxic effect of many cardiac glycosides has been demonstrated, but the mechanism of action is very complicated and complex, and Na+/K+-ATPase surely plays a crucial role in it. On the other hand, Na+/K+-ATPase is regulated by many endogenous factors, such as hormones or FXYD proteins, whose role in regulating the cell cycle has been… 

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