From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

  title={From NAFLD to NASH to cirrhosis—new insights into disease mechanisms},
  author={A. Wree and L. Broderick and A. Canbay and H. Hoffman and A. Feldstein},
  journal={Nature Reviews Gastroenterology &Hepatology},
  • A. Wree, L. Broderick, +2 authors A. Feldstein
  • Published 2013
  • Medicine
  • Nature Reviews Gastroenterology &Hepatology
  • NAFLD has evolved as a serious public health problem in the USA and around the world. In fact, NASH—the most serious form of NAFLD—is predicted to become the leading cause of liver transplantation in the USA by the year 2020. The pathogenesis of NAFLD and NASH, in particular the mechanisms responsible for liver injury and fibrosis, is the result of a complex interplay between host and environmental factors, and is at the centre of intense investigation. In this Review, we focus on recently… CONTINUE READING
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