From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

@article{Wree2013FromNT,
  title={From NAFLD to NASH to cirrhosis—new insights into disease mechanisms},
  author={A. Wree and L. Broderick and A. Canbay and H. Hoffman and A. Feldstein},
  journal={Nature Reviews Gastroenterology &Hepatology},
  year={2013},
  volume={10},
  pages={627-636}
}
  • A. Wree, L. Broderick, +2 authors A. Feldstein
  • Published 2013
  • Medicine
  • Nature Reviews Gastroenterology &Hepatology
  • NAFLD has evolved as a serious public health problem in the USA and around the world. In fact, NASH—the most serious form of NAFLD—is predicted to become the leading cause of liver transplantation in the USA by the year 2020. The pathogenesis of NAFLD and NASH, in particular the mechanisms responsible for liver injury and fibrosis, is the result of a complex interplay between host and environmental factors, and is at the centre of intense investigation. In this Review, we focus on recently… CONTINUE READING
    348 Citations

    Figures and Topics from this paper.

    The genetics of NAFLD
    • 234
    Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches
    • 18
    • PDF
    Evolving therapies for non-alcoholic steatohepatitis
    • 14
    Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH
    • 54
    • PDF
    NASH and the Cross-Talk Between the Gut and Liver
    • 3
    • PDF
    A Review of Pharmacological Treatments of NASH
    Steatosis and Steatohepatitis: Complex Disorders
    • 25
    • Highly Influenced
    Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack
    • 5
    • PDF
    Importance of iron overload and steatosis in patients with chronic liver disease

    References

    SHOWING 1-10 OF 121 REFERENCES
    The epidemiology of nonalcoholic fatty liver disease: a global perspective.
    • 643
    Good fat/bad fat
    • 66
    Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • 1,561
    • PDF
    Management of nonalcoholic steatohepatitis: an evidence-based approach.
    • 42
    Mechanisms of hepatic fibrogenesis.
    • 1,410
    • PDF