From Molecules to Memory in the Cerebellum

  title={From Molecules to Memory in the Cerebellum},
  author={David J. Linden},
  pages={1682 - 1685}
  • D. Linden
  • Published 19 September 2003
  • Biology, Psychology
  • Science
Neuroscientists have long sought to elucidate the molecular underpinnings of the memories needed to learn, for example, a motor task. In his Perspective, Linden discusses new work (Koekkoek et al.) suggesting that long-term depression in Purkinje cells mediated by protein kinase C signaling is responsible for motor memory in a task called associative eyelid conditioning. 
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In a recent report on eyeblink conditioning in mice, Koekkoek et al . ([ 1 ][1]) drew several conclusions that we believe are unsubstantiated and incorrect and fail to cite much of the relevant


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Expression of Protein Kinase C Inhibitor Blocks Cerebellar Long-Term Depression without Affecting Purkinje Cell Excitability in Alert Mice
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