From Molecules to Memory in the Cerebellum

@article{Linden2003FromMT,
  title={From Molecules to Memory in the Cerebellum},
  author={David J. Linden},
  journal={Science},
  year={2003},
  volume={301},
  pages={1682 - 1685}
}
  • D. Linden
  • Published 19 September 2003
  • Biology, Psychology
  • Science
Neuroscientists have long sought to elucidate the molecular underpinnings of the memories needed to learn, for example, a motor task. In his Perspective, Linden discusses new work (Koekkoek et al.) suggesting that long-term depression in Purkinje cells mediated by protein kinase C signaling is responsible for motor memory in a task called associative eyelid conditioning. 
Time and tide in cerebellar memory formation
Serotonergic control of the developing cerebellum
TLDR
Insight is given in the mechanism behind the serotonergic control of the cerebellum during postnatal development by using an efficient mechanism through differential expression of the receptors studied in this thesis: 5-HT1,5-HT2 and 5- HT3 receptors.
Serotonin, presynaptic 5‐HT3 receptors and synaptic plasticity in the developing cerebellum
  • R. Nichols
  • Biology, Psychology
    The Journal of physiology
  • 2011
TLDR
Hebbian modulation resulting from the parallel fibre and climbing fibre inputs onto the Purkinje cells had been postulated on the basis of their apparent anatomical interaction, and correspondingly, both long-term potentiation (LTP) and long- term depression (LTD) were later demonstrated to occur along these input pathways.
The role of CaMKII in cerebellar learning
TLDR
This thesis explored the possibility that CaMKII might be involved in this weakening process and in cerebellar motor learning, which results in synaptic weakening rather than strengthening.
development and plasticity in the cerebellum Long-term in vivo time-lapse imaging of synapse
TLDR
Development and plasticity in the cerebellum Long-term in vivo time-lapse imaging of synapse and its applications in neuroscience and regenerative medicine are studied.
The primate cortico-cerebellar system: anatomy and function
  • N. Ramnani
  • Biology, Psychology
    Nature Reviews Neuroscience
  • 2006
TLDR
The relatively well-developed models of how the cerebellum processes information from the motor cortex might be extended to explain how it could also process information from an area of origin in the cerebral cortex.
The human cerebellum contributes to motor, emotional and cognitive associative learning. A review
Comment on "Cerebellar LTD and Learning-Dependent Timing of Conditioned Eyelid Responses"
In a recent report on eyeblink conditioning in mice, Koekkoek et al . ([ 1 ][1]) drew several conclusions that we believe are unsubstantiated and incorrect and fail to cite much of the relevant
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 14 REFERENCES
New life in an old idea: The synaptic plasticity and memory hypothesis revisited
TLDR
There is now compelling evidence that changes in synaptic strength occur as a consequence of certain forms of learning, a major challenge will be to determine whether such changes constitute the memory trace itself or play a less specific supporting role in the information processing that accompanies memory formation.
Cerebellar LTD and Learning-Dependent Timing of Conditioned Eyelid Responses
TLDR
It is shown that protein kinase C–dependent long-term depression in Purkinje cells is necessary for learning-dependent timing of Pavlovian-conditioned eyeblink responses.
Long-term depression.
  • M. Ito
  • Biology
    Annual review of neuroscience
  • 1989
TLDR
Evidence is accumulating to support the cerebellar learning hypothesis as to how long the LTD lasts beyond the limit of the present maximum observation time of 3 hr, and whether and how it is eventually transformed to a permanent memory.
Organization of memory traces in the mammalian brain.
TLDR
The overriding problem for understanding memory mechanisms in the mammalian brain is localization of memory storage, and once the locus, or loci, of a given form of long-term memory has been determined, the authors should be able to analyze the mechanisms of memorystorage.
Neurobiology: Ready to unlearn
TLDR
After rabbits learn to associate a tone with a small shock near the eye, they blink when they hear the tone and activation of nerve fibres known as climbing fibres leads to 'unlearning'.
Expression of Protein Kinase C Inhibitor Blocks Cerebellar Long-Term Depression without Affecting Purkinje Cell Excitability in Alert Mice
TLDR
It is concluded that cerebellar LTD is probably one of the major mechanisms underlying motor learning, but that deficits in LTD induction and motor learning as observed in the L7-PKCI mutants may only be reflected in differences of the Purkinje cell signals during and/or directly after training.
...
1
2
...