From Molecules to Memory in the Cerebellum

@article{Linden2003FromMT,
  title={From Molecules to Memory in the Cerebellum},
  author={David J. Linden},
  journal={Science},
  year={2003},
  volume={301},
  pages={1682 - 1685}
}
  • D. Linden
  • Published 19 September 2003
  • Biology, Psychology
  • Science
Neuroscientists have long sought to elucidate the molecular underpinnings of the memories needed to learn, for example, a motor task. In his Perspective, Linden discusses new work (Koekkoek et al.) suggesting that long-term depression in Purkinje cells mediated by protein kinase C signaling is responsible for motor memory in a task called associative eyelid conditioning. 
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  • R. Nichols
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    The Journal of physiology
  • 2011
TLDR
Hebbian modulation resulting from the parallel fibre and climbing fibre inputs onto the Purkinje cells had been postulated on the basis of their apparent anatomical interaction, and correspondingly, both long-term potentiation (LTP) and long- term depression (LTD) were later demonstrated to occur along these input pathways.
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TLDR
This thesis explored the possibility that CaMKII might be involved in this weakening process and in cerebellar motor learning, which results in synaptic weakening rather than strengthening.
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Development and plasticity in the cerebellum Long-term in vivo time-lapse imaging of synapse and its applications in neuroscience and regenerative medicine are studied.
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    Nature Reviews Neuroscience
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TLDR
The relatively well-developed models of how the cerebellum processes information from the motor cortex might be extended to explain how it could also process information from an area of origin in the cerebral cortex.
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Comment on "Cerebellar LTD and Learning-Dependent Timing of Conditioned Eyelid Responses"
In a recent report on eyeblink conditioning in mice, Koekkoek et al . ([ 1 ][1]) drew several conclusions that we believe are unsubstantiated and incorrect and fail to cite much of the relevant…
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