From Modic 1 vertebral-endplate subchondral bone signal changes detected by MRI to the concept of 'active discopathy'.

Abstract

Late-1980s MRI-detected vertebral-endplate subchondral bone signal changes associated with degenerative disc disease as well as recent studies suggest that in some patients, non-specific chronic low back pain (NS cLBP) can be defined by specific clinical, radiological and biological features, for a concept of active discopathy. This concept allows for associating a particular NS cLBP phenotype to a specific anatomical lesion, namely those with Modic 1 signal changes seen on MRI. Local inflammation is thought to play a pivotal role in these changes. Other etiopathogenic processes may include local infection and mechanical or biochemical stress combined with predisposing genetic factors; treatment strategies remain debated. Modic 1 changes detected by MRI can be considered a first biomarker in NS cLBP. Such changes are of high clinical relevance because they are associated with a specific clinical phenotype and can be targeted by specific treatments.

DOI: 10.1136/annrheumdis-2015-207317

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Cite this paper

@article{Nguyen2015FromM1, title={From Modic 1 vertebral-endplate subchondral bone signal changes detected by MRI to the concept of 'active discopathy'.}, author={Christelle Nguyen and Serge Poiraudeau and François P Rannou}, journal={Annals of the rheumatic diseases}, year={2015}, volume={74 8}, pages={1488-94} }