From Levinthal to pathways to funnels

@article{Dill1997FromLT,
  title={From Levinthal to pathways to funnels},
  author={Ken A. Dill and Hue Sun Chan},
  journal={Nature Structural Biology},
  year={1997},
  volume={4},
  pages={10-19}
}
  • K. Dill, H. Chan
  • Published 1997
  • Chemistry, Medicine
  • Nature Structural Biology
While the classical view of protein folding kinetics relies on phenomenological models, and regards folding intermediates in a structural way, the new view emphasizes the ensemble nature of protein conformations. Although folding has sometimes been regarded as a linear sequence of events, the new view sees folding as parallel microscopic multi-pathway diffusion-like processes. While the classical view invoked pathways to solve the problem of searching for the needle in the haystack, the pathway… Expand
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  • Proceedings of the National Academy of Sciences
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