From Levinthal to pathways to funnels

  title={From Levinthal to pathways to funnels},
  author={Ken A. Dill and Hue Sun Chan},
  journal={Nature Structural Biology},
While the classical view of protein folding kinetics relies on phenomenological models, and regards folding intermediates in a structural way, the new view emphasizes the ensemble nature of protein conformations. Although folding has sometimes been regarded as a linear sequence of events, the new view sees folding as parallel microscopic multi-pathway diffusion-like processes. While the classical view invoked pathways to solve the problem of searching for the needle in the haystack, the pathway… 

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