From Kratom to mitragynine and its derivatives: Physiological and behavioural effects related to use, abuse, and addiction

@article{Hassan2013FromKT,
  title={From Kratom to mitragynine and its derivatives: Physiological and behavioural effects related to use, abuse, and addiction},
  author={Zurina Hassan and Mustapha Muzaimi and Visweswaran Navaratnam and Nurul H. M. Yusoff and Farah Wahida Suhaimi and Raja Kumar Vadivelu and Balasingam Kasinather Vicknasingam and Davide Amato and Stephan von H{\"o}rsten and Nurul Iman W. Ismail and Nanthini Jayabalan and Ammar Imad Hazim and Sharif Mahsofi Mansor and Christian P. M{\"u}ller},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2013},
  volume={37},
  pages={138-151}
}
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The traditional and medicinal uses of kratom are reviewed along with the synthesis of its bioactive ingredients, their pharmacology, metabolism, and structure-activity relationships, and the importance in society of this currently controversial substance are discussed.
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Current researchs on its main indole alkaloid, mitragynine suggest both therapeutic and addictive potential but further research on its molecular effects is needed.
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Until studies are conducted that define kratom's role in treating opioid withdrawal and/or other central nervous system conditions, kratom will likely remain available as a dietary supplement for the foreseeable future.
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TLDR
There are currently no standard analytical screening techniques for mitragynine and its metabolites following ingestion limiting its detection to more sophisticated techniques like liquid chromatography-mass spectrometry to determine kratom use.
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References

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