From Ionic Currents to Molecular Mechanisms The Structure and Function of Voltage-Gated Sodium Channels

  title={From Ionic Currents to Molecular Mechanisms The Structure and Function of Voltage-Gated Sodium Channels},
  author={W. Catterall},
  • W. Catterall
  • Published 2000
  • Chemistry, Medicine
  • Neuron
  • tetrodotoxin binding activity and a protein of ‫072ف‬ kDa (Agnew et al., 1980). Subsequent purification studies showed that the sodium channel from mammalian brain is a complex of ␣ al., 1982), the tetrodotoxin-binding component of the sodium channel purified from eel electroplax is a single Voltage-gated sodium channels are responsible for the protein of 270 kDa (Miller et al., 1983), and the sodium rising phase of the action potential in the membranes channel from skeletal muscle is a complex… CONTINUE READING
    1,855 Citations

    Figures, Tables, and Topics from this paper

    Regulatory Role of Voltage-Gated Na+ Channel β Subunits in Sensory Neurons
    • 33
    • PDF
    Forty Years of Sodium Channels: Structure, Function, Pharmacology, and Epilepsy
    • 48
    Nomenclature of Voltage-Gated Sodium Channels
    • 1,354
    Mechanisms of Drug Binding to Voltage-Gated Sodium Channels.
    • 6
    An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart
    • 287
    • PDF
    Voltage-Gated Sodium Channels
    • 2
    • PDF
    Roles of the ion channel NALCN in neuronal excitability control


    Existence of distinct sodium channel messenger RNAs in rat brain
    • 810
    Expression of functional sodium channels from cloned cDNA
    • 495
    Functional reconstitution of the purified brain sodium channel in planar lipid bilayers.
    • 142
    • PDF
    Pore properties of rat brain II sodium channels mutated in the selectivity filter domain
    • 108
    Purification and functional reconstitution of the voltage-sensitive sodium channel from rabbit T-tubular membranes.
    • 75
    Molecular localization of an ion-binding site within the pore of mammalian sodium channels.
    • 260
    Voltage-dependent activation in purified reconstituted sodium channels from rabbit T-tubular membranes.
    • 34
    • PDF