From Ionic Currents to Molecular Mechanisms The Structure and Function of Voltage-Gated Sodium Channels

@article{Catterall2000FromIC,
  title={From Ionic Currents to Molecular Mechanisms The Structure and Function of Voltage-Gated Sodium Channels},
  author={W. A. Catterall},
  journal={Neuron},
  year={2000},
  volume={26},
  pages={13-25}
}
tetrodotoxin binding activity and a protein of ‫072ف‬ kDa (Agnew et al., 1980). Subsequent purification studies showed that the sodium channel from mammalian brain is a complex of ␣ al., 1982), the tetrodotoxin-binding component of the sodium channel purified from eel electroplax is a single Voltage-gated sodium channels are responsible for the protein of 270 kDa (Miller et al., 1983), and the sodium rising phase of the action potential in the membranes channel from skeletal muscle is a complex… Expand
Regulatory Role of Voltage-Gated Na+ Channel β Subunits in Sensory Neurons
TLDR
The purpose of this review is to provide a broad overview of β subunit expression and function in peripheral sensory neurons and examine their contributions to neuropathic pain. Expand
Forty Years of Sodium Channels: Structure, Function, Pharmacology, and Epilepsy
TLDR
Developing knowledge of sodium channels is used to help understand the pathophysiology and to suggest potential therapeutic approaches for this devastating childhood disease Dravet Syndrome. Expand
Nomenclature of Voltage-Gated Sodium Channels
TLDR
The present alphabetical nomenclature does not reveal the structural relationships among the α1 subunits of Ca2+ channels, but it is apparent that these two alphabeticals will overlap at α1L, which may not mediate an L-type Ca2- current and therefore may create confusion. Expand
The voltage-sensitive sodium channel is a bell-shaped molecule with several cavities
TLDR
The three-dimensional structure of the voltage-sensitive sodium channel from the eel Electrophorus electricus is presented and it is shown that the channel has several inner cavities connected to four small holes and eight orifices close to the extracellular and cytoplasmic membrane surfaces. Expand
Mechanisms of Drug Binding to Voltage-Gated Sodium Channels.
TLDR
The purpose of this chapter is to broadly review the mechanisms of Na+ channel gating and the models used to describe drug binding andNa+ channel inhibition. Expand
Voltage-Gated Sodium Channels: Structure, Function, and Pathophysiology
Voltage-gated sodium channels initiate action potentials in neurons, muscle, and other excitable cells. They are complexes of a large α subunit with one or two smaller β subunits. The α subunitsExpand
The biology of voltage-gatedsodium channels
TLDR
The basic functional properties of sodium channels and their role in various excitation phenomena in nerve and muscle are reviewed; this is followed by a brief account of the current state of knowledge of the molecular mechanism of these sodium channel functions. Expand
An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart
TLDR
The results suggest that the principal cardiac isoform in the intercalated disks is primarily responsible for action potential conduction between cells and reveal an unexpected role for brain sodium channel isoforms in the transverse tubules in coupling electrical excitation to contraction in cardiac muscle. Expand
Voltage-Gated Sodium Channels
Voltage-gated sodium channels subserve regenerative excitation throughout the nervous system, as well as in skeletal and cardiac muscle. This excitation results from a voltage-dependent mechanismExpand
Voltage-Gated Sodium Channels: Biophysics, Pharmacology, and Related Channelopathies
TLDR
The structure, function, and biophysical properties of VGSC as well as their pharmacology and associated channelopathies are outlined and some of the recent advances in this field are highlighted. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 246 REFERENCES
Existence of distinct sodium channel messenger RNAs in rat brain
The sodium channel is a voltage-gated ionic channel essential for the generation of action potentials1–3. It has been reported that the sodium channels purified from the electric organ ofExpand
Expression of functional sodium channels from cloned cDNA
TLDR
It is reported that the messenger RNAs generated by transcription of the cloned cDNAs encoding the rat brain sodium channel large polypeptides, when injected into Xenopus oocytes, can direct the formation of functional sodium channels. Expand
Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel.
TLDR
Results indicate that the beta 1 subunit is crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the rat brain sodium channel. Expand
Functional reconstitution of the purified brain sodium channel in planar lipid bilayers.
TLDR
This study demonstrates that the purified brain sodium channel--which consists of three polypeptide subunits: alpha, beta 1, and beta 2--exhibits the same voltage dependence, neurotoxin sensitivity, and ionic selectivity associated with native sodium channels. Expand
Pore properties of rat brain II sodium channels mutated in the selectivity filter domain
TLDR
In all mutant channels tested, even those with the same net charge in the ring structure as the wild type, the selectivity for Na+ and Li+ over K+, Rb+, Cs+, and NH4+ was significantly reduced and changes in charge did not correlate in a simple fashion with the single-channel conductances. Expand
On the Structural Basis for Size-selective Permeation of Organic Cations through the Voltage-gated Sodium Channel
Recent evidence indicates that ionic selectivity in voltage-gated Na+ channels is mediated by a small number of residues in P-region segments that link transmembrane elements S5 and S6 in each ofExpand
Purification and functional reconstitution of the voltage-sensitive sodium channel from rabbit T-tubular membranes.
TLDR
The voltage-sensitive sodium channel has been purified from rabbit T-tubular membranes and reconstituted into defined phospholipid vesicles and retained the ability to gate specific 22Na+ influx in response to activation by batrachotoxin or veratridine. Expand
Molecular localization of an ion-binding site within the pore of mammalian sodium channels.
TLDR
Mutation of Tyr401 to Cys, the corresponding residue in the cardiac sequence, rendered microliters highly susceptible to cadmium blockage but resistant to TTX, thus defining the position of a critical residue within the sodium channel pore. Expand
Voltage-dependent activation in purified reconstituted sodium channels from rabbit T-tubular membranes.
TLDR
The voltage-dependent activation of the batrachotoxin-modified reconstituted channel is the same as that seen with native channels in situ or in bilayers after exposure to this toxin. Expand
Calcium channel characteristics conferred on the sodium channel by single mutations
TLDR
The effects on ion selectivity of replacing lysine at position 1,422 in repeat III and/or alanine in repeat IV of rat sodium channel II are reported, suggesting that these residues constitute part of the selectivity filter of the channel. Expand
...
1
2
3
4
5
...