From Ionic Currents to Molecular Mechanisms The Structure and Function of Voltage-Gated Sodium Channels

  title={From Ionic Currents to Molecular Mechanisms The Structure and Function of Voltage-Gated Sodium Channels},
  author={W. Catterall},
  • W. Catterall
  • Published 2000
  • Medicine, Biology
  • Neuron
  • tetrodotoxin binding activity and a protein of ‫072ف‬ kDa (Agnew et al., 1980). Subsequent purification studies showed that the sodium channel from mammalian brain is a complex of ␣ al., 1982), the tetrodotoxin-binding component of the sodium channel purified from eel electroplax is a single Voltage-gated sodium channels are responsible for the protein of 270 kDa (Miller et al., 1983), and the sodium rising phase of the action potential in the membranes channel from skeletal muscle is a complex… CONTINUE READING
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