From DNA sequence analysis to modeling replication in the human genome.

@article{Brodie2005FromDS,
  title={From DNA sequence analysis to modeling replication in the human genome.},
  author={Edward-Benedict Brodie of Brodie and Samuel Nicolay and Marie Touchon and Benjamin Audit and Yves D'Aubenton-Carafa and Claude Thermes and Alain Arneodo},
  journal={Physical review letters},
  year={2005},
  volume={94 24},
  pages={248103}
}
We explore the large-scale behavior of nucleotide compositional strand asymmetries along human chromosomes. As we observe for 7 of 9 origins of replication experimentally identified so far, the (TA+GC) skew displays rather sharp upward jumps, with a linear decreasing profile in between two successive jumps. We present a model of replication with well positioned replication origins and random terminations that accounts for the observed characteristic serrated skew profiles. We succeed in… CONTINUE READING

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