From DEPARTMENT OF MEDICINE, DIVISION OF HEMATOLOGY Karolinska Institutet, Stockholm, Sweden MOLECULAR ALTERATIONS AND CLONAL EVOLUTION IN ACUTE MYELOID LEUKEMIA: PROGNOSTIC AND THERAPEUTIC IMPLICATIONS

Abstract

Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic stem cells characterized by inhibition of differentiation, subsequent accumulation of incomplete matured cells at various stages and reduced production of healthy hematopoietic elements. Despite significant progress, the outcome of AML is variable and often suboptimal. Many patients will… (More)

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