From Clinical Research to Clinical Practice: A 4-Year Review of Ziprasidone

@article{Nemeroff2005FromCR,
  title={From Clinical Research to Clinical Practice: A 4-Year Review of Ziprasidone},
  author={Charles B. Nemeroff and Jeffrey A. Lieberman and Peter J. Weiden and Philip D. Harvey and John W. Newcomer and Alan F. Schatzberg and Clinton D. Kilts and David G. Daniel},
  journal={CNS Spectrums},
  year={2005},
  volume={10},
  pages={1 - 20}
}
ABSTRACT Ziprasidone is a second-generation antipsychotic that received Food and Drug Administration approval in February 2001. It has a unique receptor profile that includes high-affinity antagonist activity at dopamine D2 receptors, inverse agonist activity at serotonin (5-HT)2A receptors, agonist activity at 5-HT1A receptors, and a relatively high affinity for the serotonin and norepinephrine transporters. The 5-HT1A affinity, together with the inhibitory effect on monoamine reuptake, may… 

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Ziprasidone was well tolerated, and patients demonstrated significant improvement in metabolic parameters and in all movement disorder assessments, as well as in intent-to-treat population.

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...

References

SHOWING 1-10 OF 152 REFERENCES

Oral ziprasidone in the treatment of schizophrenia: a review of short-term trials.

  • J. Kane
  • Psychology, Medicine
    The Journal of clinical psychiatry
  • 2003
TLDR
Atypical antipsychotic ziprasidone has been shown in placebo- and active-comparator-controlled clinical studies to be effective in treating the positive, negative, and affective symptoms of schizophrenia.

Ziprasidone augmentation of selective serotonin reuptake inhibitors (SSRIs) for SSRI-resistant major depressive disorder.

TLDR
A possible augmentation role for ziprasidone when used in conjunction with SSRIs in SSRI-resistant MDD is suggested, with no clinically significant QTc prolongation or severe adverse events observed in any of the study participants.

The psychopharmacology of ziprasidone: receptor-binding properties and real-world psychiatric practice.

TLDR
Ziprasidone targets the key hypothetical neurochemical disturbance in psychosis-excessive dopamine neurotransmission at dopamine D2 receptors in the mesolimbic pathway of the brain-presumably responsible for the positive symptoms of schizophrenia.

Effects of atypical antipsychotics on the syndromal profile in treatment-resistant schizophrenia.

TLDR
It is confirmed that atypicals are associated with improvement of an expanded spectrum of symptoms in treatment-resistant patients as well as traditional antipsychotic treatment with all 3 atypical medications.

Effectiveness of switching to ziprasidone for stable but symptomatic outpatients with schizophrenia.

TLDR
It is suggested that outpatients who partially respond to conventional antipsychotics, risperidone, or olanzapine may experience improved control of psychotic symptoms following a switch to ziprasidone.

Olanzapine: an updated review of its use in the management of schizophrenia.

TLDR
Olanzapine demonstrated superior antipsychotic efficacy compared with haloperidol in the treatment of acute phase schizophrenia, and in thetreatment of some patients with first-episode or treatment-resistant schizophrenia.

A PET study of dopamine D2 and serotonin 5-HT2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone.

TLDR
It is affirm that ziprasidone is similar to other novel antipsychotics in having greater 5-HT(2) than D( 2) receptor occupancy at therapeutic doses and suggest that the optimal effective dose of ziprasIDone is closer to 120 mg/day than to the lower doses suggested by previous PET studies.

Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.

TLDR
Olanzapine was the most effective in terms of the rates of discontinuation, and the efficacy of the conventional antipsychotic agent perphenazine appeared similar to that of quetiapine, risperidone, and ziprasidone.
...