From Cell Structure to Transcription: Hippo Forges a New Path

@article{Edgar2006FromCS,
  title={From Cell Structure to Transcription: Hippo Forges a New Path},
  author={Bruce A Edgar},
  journal={Cell},
  year={2006},
  volume={124},
  pages={267-273}
}
The control of cell number during animal development is a longstanding puzzle. Recent studies in the fruit fly Drosophila melanogaster have defined a new signaling pathway that restricts cell proliferation in differentiating epithelia. The cytoskeletal proteins Merlin and Expanded, which play a role in cell adhesion and structure, control the activation of the Hippo/Salvador kinase complex, which in turn activates the Warts/Mats kinase complex. Warts/Mats kinase phosphorylates and inhibits… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 149 extracted citations

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.

The Journal of clinical investigation • 2012
View 4 Excerpts
Highly Influenced

Growth Regulation: A Beginning for the Hippo Pathway

Current Biology • 2006
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2005
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…