From Cell Structure to Transcription: Hippo Forges a New Path

  title={From Cell Structure to Transcription: Hippo Forges a New Path},
  author={Bruce A Edgar},
The control of cell number during animal development is a longstanding puzzle. Recent studies in the fruit fly Drosophila melanogaster have defined a new signaling pathway that restricts cell proliferation in differentiating epithelia. The cytoskeletal proteins Merlin and Expanded, which play a role in cell adhesion and structure, control the activation of the Hippo/Salvador kinase complex, which in turn activates the Warts/Mats kinase complex. Warts/Mats kinase phosphorylates and inhibits… CONTINUE READING
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