From Binary to Multivalued to Continuous Models: The Lac Operon as a Case Study

@article{Franke2010FromBT,
  title={From Binary to Multivalued to Continuous Models: The Lac Operon as a Case Study},
  author={Raimo Franke and Fabian J. Theis and Steffen Klamt},
  journal={Journal of integrative bioinformatics},
  year={2010},
  volume={7 1}
}
Using the lac operon as a paradigmatic example for a gene regulatory system in prokaryotes, we demonstrate how qualitative knowledge can be initially captured using simple discrete (Boolean) models and then stepwise refined to multivalued logical models and finally to continuous (ODE) models. At all stages, signal transduction and transcriptional regulation is integrated in the model description. We first show the potential benefit of a discrete binary approach and discuss then problems and… CONTINUE READING
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