From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation

  title={From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation},
  author={Ken Howick and Brendan T. Griffin and John F. Cryan and Harri{\"e}t Schellekens},
  journal={International Journal of Molecular Sciences},
Ghrelin is the only known peripherally-derived orexigenic hormone, increasing appetite and subsequent food intake. The ghrelinergic system has therefore received considerable attention as a therapeutic target to reduce appetite in obesity as well as to stimulate food intake in conditions of anorexia, malnutrition and cachexia. As the therapeutic potential of targeting this hormone becomes clearer, it is apparent that its pleiotropic actions span both the central nervous system and peripheral… 

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