From B cell to plasma cell

@article{Borghesi2006FromBC,
  title={From B cell to plasma cell},
  author={Lisa A. Borghesi and Christine Milcarek},
  journal={Immunologic Research},
  year={2006},
  volume={36},
  pages={27-32}
}
B cell development culminates in the formation of plasma cells, potent secretors of the immunoglobulins (Ig), proteins crucial for the health of the organism. Two distinctive and crucial steps are required during B cell differentiation. First, variable gene segments encoding the antigen-binding region of Ig undergo directed rearrangement through a process known as V(D)J recombination. Second, alternative processing of the Ig heavy chain mRNA transcript enables plasma cells to secrete high… 
View on Springer
ncbi.nlm.nih.gov
51 Citations
Highly Influential Citations
3
Background Citations
23

51 Citations

The role of B7 family members in the generation of Immunoglobulin

The recent advance of the effects of B7 family members on Ig production and relative diseases is reviewed and summarized.

Plasma cell formation, secretion, and persistence: the short and the long of it.

The overall result is a large shift in RNA processing to the secretory-specific form of immunoglobulin (Ig) heavy chain mRNA and an upregulation of Igh mRNA amounts, associated with the large-scale induction of Ig protein synthesis and the unfolded protein response to accommodate the massive quantity of secretory Ig that results.

B-cell receptor signaling as a driver of lymphoma development and evolution.

Antigen-Antibody Complexes.

The main scope of this chapter is to discuss the structure and function of different classes of antibodies and the various aspects of antigen-antibody interactions including antigens in complexes, with a special focus on paratopes, complementarity determining regions (CDRs) and other non-CDR residues important for antigen binding and recognition.

Regulated versus Constitutive Secretion – A Major Form of Intercellular Communication

Serum immunoglobulin levels in patients with lymphoproliferative diseases in Erbil, Kurdistan region, Iraq

There were some conflicting data regarding serum immunoglobulin levels in newly diagnosed patients with lymphoproliferative disorders in Erbil, Iraq.

Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination

The pleiotropic effects of some of the extracellular signals that affect myelination are reviewed and the cellular processes used by the source cells that contribute to the variation in the temporal and spatial availability of the signals are discussed.

A Review on: Antibody Engineering for Development of Therapeutic Antibodies

Now a days, scientists are using transgenic animals and plants to produce specific antibodies (monoclonal antibodies) and are showing an innovative promise in future to solve many disease cost problems both in animal and human.

Vertebrate and Invertebrate Respiratory Proteins, Lipoproteins and other Body Fluid Proteins

This book focuses on respiratory proteins, the broad hemoglobin family, as well as the molluscan and arachnid hemocyanins (and their multifunctional roles) and a number of other proteins, such as the hemerythrins; serum albumin; serum amyloid A; von Willebrand factor and its interaction with factor VIII; and C-reactive protein.

Increased Gene Targeting in Ku70 and Xrcc4 Transiently Deficient Human Somatic Cells

It is demonstrated that the transient knockdown of integral NHEJ proteins, Ku70 and Xrcc4, by RNAi in human HCT116 cells has a remarkable effect on gene targeting/random insertions ratios and is a viable approach to increase the frequency of gene targeting events.
...

References

SHOWING 1-10 OF 33 REFERENCES

Modular Nature of Blimp-1 in the Regulation of Gene Expression during B Cell Maturation1

DNA microarrays were used to analyze the transcription profiles of both Blimp-1-transduced murine B cell lines and the inducible B cell line BCL1, suggesting that the transition from a B cell to plasma cell can occur in multiple ways, perhaps accounting for the different types of Ab-secreting cells observed in vivo.

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

Functional analysis demonstrates that the proliferative response to IL-7, an early B lineage growth factor, is restricted to S7+ stages and, furthermore, that an additional, cell contact-mediated signal is essential for survival of Fr.

Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow.

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

Identification of the earliest B lineage stage in mouse bone marrow.

B Lineage–specific Regulation of V(D)J Recombinase Activity Is Established in Common Lymphoid Progenitors

It is demonstrated that V(D)J rearrangements are detectable at IgH loci in ∼5% of splenic natural killer cells, and it is shown that recombinase activity in CLPs is largely controlled by the Erag enhancer.

Induction of Early B Cell Factor (EBF) and Multiple B Lineage Genes by the Basic Helix-Loop-Helix Transcription Factor E12

It is found that the conversion of 70Z/3 pre-B lymphocytes to cells with a macrophage-like phenotype is associated with the loss of E2A and EBF and together these transcription factors coordinately regulate numerous B lineage–associated genes.

Developmental Separation of V(D)J Recombinase Expression and Initiation of IgH Recombination in B Lineage Progenitors In Vivo

It is found that single B lineage precursors express an active V(D)J recombinase in vivo before the stage when IgH rearrangements are frequently detectable, indicating that the onset of recombin enzyme activity and the initiation of IgH recombination are developmentally distinct events in the B lineage.

E47 is required for V(D)J recombinase activity in common lymphoid progenitors

It is shown that loss of the transcription factor E47 produces a reduced CLP population that lacks V(D)J recombinase activity and D-JH rearrangements in vivo, and a role for E47 in regulating lineage progression at the CLP stage in vivo is defined.

A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.