From ‘protein’ to the beginnings of clinical proteomics
@article{Perrett2007FromT, title={From ‘protein’ to the beginnings of clinical proteomics}, author={D. Perrett}, journal={PROTEOMICS – Clinical Applications}, year={2007}, volume={1} }
It has taken over 200 years to move from the view that there was a single unique ‘protein’ to our present understanding that there may be over a million proteins in the human body. This review details the technological developments that led to this increase in knowledge especially in the area of clinical biochemistry. Simple techniques such as total protein assays allowed the quantitation of the amounts of protein in blood plasma and serum. These techniques were then linked to simple… CONTINUE READING
Topics from this paper
29 Citations
On the binding affinity of macromolecular interactions: daring to ask why proteins interact
- Chemistry, Medicine
- Journal of The Royal Society Interface
- 2013
- 265
- PDF
Development of nanoflow liquid chromatography-nanoelectrospray ionization mass spectrometry methodology for improved urine metabolomics
- Chemistry
- 2015
- PDF
Network-based inference of protein function and disease-gene association
- Biology, Computer Science
- 2012
- Highly Influenced
- PDF
Large-Scale Analysis of Microtubule Pharmacology via Phosphoproteomics and High-Content Imaging
- Chemistry
- 2018
Electrophoretic separations on paper: Past, present, and future-A review.
- Chemistry, Medicine
- Analytica chimica acta
- 2017
- 12
Critical evaluation of ninhydrin for monitoring surgical instrument decontamination.
- Medicine
- The Journal of hospital infection
- 2013
- 8
References
SHOWING 1-10 OF 112 REFERENCES
Grouped Variations in the Occurrence of New Protein Components in Normal Human Serum
- Chemistry, Medicine
- Nature
- 1955
- 128
Protein mapping by combined isoelectric focusing and electrophoresis of mouse tissues
- Biology, Medicine
- Humangenetik
- 2004
- 996
Electrophoresis: the march of pennies, the march of dimes.
- Chemistry, Medicine
- Journal of chromatography. A
- 2005
- 81
Determination of serum proteins by means of the biuret reaction.
- Medicine, Biology
- The Journal of biological chemistry
- 1949
- 13,281
- PDF
Zone electrophoresis in starch gels and its application to studies of serum proteins.
- Chemistry, Medicine
- Advances in protein chemistry
- 1959
- 549
A study of the partial acid hydrolysis of some proteins, with special reference to the mode of linkage of the basic amino-acids.
- Chemistry, Medicine
- The Biochemical journal
- 1941
- 47
- PDF
Progress with gene‐product mapping of the Mollicutes: Mycoplasma genitalium
- Biology, Medicine
- Electrophoresis
- 1995
- 896
Joachim kohn (1912-1987) and the origin of cellulose acetate electrophoresis.
- Chemistry, Medicine
- Clinical chemistry
- 2005
- 13
- PDF