From "carpet" mechanism to de-novo designed diastereomeric cell-selective antimicrobial peptides.

@article{Shai2001FromM,
  title={From "carpet" mechanism to de-novo designed diastereomeric cell-selective antimicrobial peptides.},
  author={Yechiel Shai and Ziv Oren},
  journal={Peptides},
  year={2001},
  volume={22 10},
  pages={1629-41}
}
Living organisms of all types produce a large repertoire of gene-encoded, net positively charged, antimicrobial peptides as part of their innate immunity to microbial invasion. Despite significant variations in composition, length and secondary structure most antimicrobial peptides are active in micromolar concentrations, suggesting a common general mechanism for their mode of action. Many antimicrobial peptides bind bacterial phospholipid membranes up to a threshold concentration, followed by… CONTINUE READING

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