Frizzled regulation of Notch signalling polarizes cell fate in the  Drosophila eye

@article{Cooper1999FrizzledRO,
  title={Frizzled regulation of Notch signalling polarizes cell fate in the  Drosophila eye},
  author={Michael Cooper and Sarah J Bray},
  journal={Nature},
  year={1999},
  volume={397},
  pages={526-530}
}
The Drosophila eye, a paradigm for epithelial organization, is highly polarized with mirror-image symmetry about the equator. The R3 and R4 photoreceptors in each ommatidium are vital in this polarity; they adopt asymmetrical positions in adult ommatidia and are the site of action for several essential genes,,,,. Two such genes are frizzled (fz) and dishevelled (dsh), the products of which are components of a signalling pathway required in R3, and which are thought to be activated by a… CONTINUE READING
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