Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis.

@article{Deardorff1998Frizzled8IE,
  title={Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis.},
  author={Matthew A Deardorff and Change Tan and Liza J Conrad and Peter G. Klein},
  journal={Development},
  year={1998},
  volume={125 14},
  pages={2687-700}
}
Wnts are secreted signaling molecules implicated in a large number of developmental processes. Frizzled proteins have been identified as likely receptors for Wnt ligands in vertebrates and invertebrates, but a functional role for vertebrate frizzleds has not yet been defined. To assess the endogenous role of frizzled proteins during vertebrate development, we have identified and characterized a Xenopus frizzled gene (xfz8). It is highly expressed in the deep cells of the Spemann organizer prior… CONTINUE READING

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