Frizzled-7 as a potential therapeutic target in colorectal cancer.

  title={Frizzled-7 as a potential therapeutic target in colorectal cancer.},
  author={Koji Ueno and Mikako Hiura and Yutaka Suehiro and Shoichi Hazama and Hiroshi Hirata and Masaaki Oka and Kohzoh Imai and Rajvir Dahiya and Yuji Hinoda},
  volume={10 7},
We investigated whether one of the Wnt receptors, frizzled-7 (FZD7), functions in the canonical Wnt signaling pathway of colorectal cancer (CRC) cells harboring an APC or CTNNB1 mutation and may be a potential therapeutic target for sporadic CRCs. The expression level of FZD gene family members in colon cancer cells and primary CRC tissues were determined by real-time PCR. Activation of the Wnt signaling pathway was evaluated by TOPflash assay. The expression level of Wnt target genes was… CONTINUE READING
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