Fritz: a secreted frizzled-related protein that inhibits Wnt activity

  title={Fritz: a secreted frizzled-related protein that inhibits Wnt activity},
  author={Thomas Mayr and Urban Deutsch and Michael K{\"u}hl and Hannes C.A Drexler and Friedrich Lottspeich and Rainer Deutzmann and Doris Wedlich and Werner Risau},
  journal={Mechanisms of Development},
Signaling molecules of the Wnt gene family are involved in the regulation of dorso-ventral, segmental and tissue polarity in Xenopus and Drosophila embryos. Members of the frizzled gene family, such as Drosophila frizzled-2 and rat frizzled-1, have been shown encode Wnt binding activity and to engage intracellular signal transduction molecules known to be part of the Wnt signaling pathway. Here we describe the cloning and characterization of Fritz, a mouse (mfiz) and human (hfiz) gene which… CONTINUE READING


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