Fringe forms a complex with Notch

  title={Fringe forms a complex with Notch},
  author={Bong-gun Ju and Sangyun Jeong and Eunkyung Bae and Seogang Hyun and Sean B. Carroll and Jeongbin Yim and Jaeseob Kim},
The Fringe protein of Drosophila and its vertebrate homologues function in boundary determination during pattern formation. Fringe has been proposed to inhibit Serrate–Notch signalling but to potentiate Delta–Notch signalling. Here we show that Fringe and Notch form a complex through both the Lin–Notch repeats and the epidermal growth factor repeats 22–36 (EGF22–36) of Notch when they are co-expressed. The Abruptex59b(Ax59b) and AxM1 mutations, which are caused by missense mutations in EGF… CONTINUE READING

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