Friends and foes in synaptic transmission: the role of tomosyn in vesicle priming.

@article{Ashery2009FriendsAF,
  title={Friends and foes in synaptic transmission: the role of tomosyn in vesicle priming.},
  author={Uri Ashery and Noa Bielopolski and Boaz Barak and Ofer Yizhar},
  journal={Trends in neurosciences},
  year={2009},
  volume={32 5},
  pages={275-82}
}
Priming is the process by which vesicles become available for fusion at nerve terminals and is modulated by numerous proteins and second messengers. One of the prominent members of this diverse family is tomosyn. Tomosyn has been identified as a syntaxin-binding protein; it inhibits vesicle priming, but its mode of action is not fully understood. The inhibitory activity of tomosyn depends on its N-terminal WD40-repeat domain and is regulated by the binding of its SNARE motif to syntaxin. Here… CONTINUE READING