Friendly and dangerous signals: is the tissue in control?

  title={Friendly and dangerous signals: is the tissue in control?},
  author={Polly Matzinger},
  journal={Nature Immunology},
In their own defense, tissues send a panoply of signals that initiate immunity and guide the choice of effector class. T(H)1-T(H)2 and T(reg) is far too simple a representation of the breathtaking variety of the resulting responses. 
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