Friedrich Feyrter: A Precise Intellect in a Diffuse System

@article{Champaneria2006FriedrichFA,
  title={Friedrich Feyrter: A Precise Intellect in a Diffuse System},
  author={Manish C. Champaneria and Irvin Mark Modlin and Mark Kidd and Geeta N. Eick},
  journal={Neuroendocrinology},
  year={2006},
  volume={83},
  pages={394 - 404}
}
Prior to the contributions of Friedrich Feyrter (1895–1973), the regulation of gastrointestinal function was an ill-understood field that was polarized by a combination of the inability of clinical scientists to perceive the relationship between the cellular elements of ‘nervism’ and the newly recognized chemical messenger system. Feyrter, an Austrian pathologist of luminescent intellect and possessed of rigorous analytic capacity, recognized the interface of the divergent elements (neural and… 

Figures from this paper

Paracrinicity: The Story of 30 Years of Cellular Pituitary Crosstalk
  • C. Denef
  • Biology
    Journal of neuroendocrinology
  • 2008
TLDR
In the anterior pituitary, paracrine communication and autocrine loops that operate during fetal and postnatal development in mammals and lower vertebrates have been shown in all hormonal cell types and in folliculo‐stellate cells.
3D analysis of the whole subcutaneous adipose tissue reveals a complex spatial network of interconnected lobules with heterogeneous browning ability
TLDR
A method that combines tissue clearing, acquisition of autofluorescence or lectin signals by confocal microscopy, segmentation procedures based on contrast enhancement, and a new semi-automatic image analysis process reveals that subcutaneous adipose tissue exhibits a subtle functional heterogeneity with partitioned areas, and opens new perspectives towards understanding its functioning and plasticity.
Neuroendokrine Neoplasien
TLDR
The morphological NEN dichotomy is supported by differences in epidemiology, genetics, clinics, and prognosis, and potentially has its cause originating from different progenitor cells.
Neuroendokrine Neoplasien
TLDR
The morphological NEN dichotomy is supported by differences in epidemiology, genetics, clinics, and prognosis, and potentially has its cause originating from different progenitor cells.
Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence
TLDR
In most patients, DIPNECH was associated with a good prognosis, with chronological progression into a subsequent carcinoid tumor noted in only one patient and death attributed directly to DIPnECH in only two patients, and there is no best evidence to support the use of octreotide, steroids, or bronchodilators in DIPE patients.
A rare case of primary malignant small cell carcinoma combined with urothelial cell carcinoma in the ureter
TLDR
Although its clinical behaviour and diagnostic modalities have not been determined and it has yet to be diagnosed immunohistopathologically, multimodality treatment including surgery, chemotherapy and radiotherapy may improve patient survival.
Uterus neuroendocrine tumor - a severe prognostic factor in a female patient with alcoholic cirrhosis undergoing chronic hemodialysis.
TLDR
An unusual case of uterus neuroendocrine tumor with multiple metastases in a 49-year-old female hemodialyzed patient with a history of alcoholic liver cirrhosis and uterus fibromatous is presented.
Tailoring Radionuclide Therapy of Neuroendocrine Tumors - Bridging the Gaps
TLDR
Tailoring radionuclide treatment based on individual dosimetry is feasible and safe, and leads to considerable interindividual variations in the number of treament cycles received.
...
1
2
...

References

SHOWING 1-10 OF 103 REFERENCES
The neuroendocrine phenotype, cellular plasticity, and the search for genetic switches: redefining the diffuse neuroendocrine system.
TLDR
It is proposed to redefine previous "neuroendocrine" concepts to include the notion that activation of specific genetic switches can lead to the expression of a partial or full neuroendocrine phenotype in a variety of cell types, including immune cells.
THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT
  • A. Pearse
  • Biology
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 1969
TLDR
A group of apparently unrelated endocrine cells, some in endocrine glands, others in nonendocrine tissues, share a number of cytochemical and ultrastructural characteristics which indicate the possession of a common metabolic pattern and common synthetic, storage and secretion mechanisms.
5-Hydroxytryptamine in a Carcinoid Tumour
ERSPAMER1 was the first to assume enterochromaffine cells of the gastrointestinal tract to contain enteramine (5-hydroxytryptamine serotonin). Feyrter2 regarded these cells as a part of the entity he
The functional characterization of normal and neoplastic human enterochromaffin cells.
TLDR
These data support novel methodology to purify live human EC cells for functional characterization and transcriptome assessment, which will allow identification of new targets to control the secretion and proliferation of SI carcinoids.
Common cytochemical and ultrastructural characteristics of cells producing polypeptide hormones (the APUD series) and their relevance to thyroid and ultimobranchial C cells and calcitonin
  • A. Pearse
  • Biology
    Proceedings of the Royal Society of London. Series B. Biological Sciences
  • 1968
TLDR
It is suggested that the remaining cells in the APUD series (pancreatic islet α1 cells, intestinal enterochromaffin cells, gastric and other argyrophil cells) are likely to have, as their primary function, the synthesis and secretion of polypeptides.
The diffuse neuroendocrine system. Studies of this newly discovered controlling system in health and disease.
  • J. Polak, S. Bloom
  • Biology, Medicine
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 1979
TLDR
Two immunological methods, radioimmunoassay and immunocytochemistry, have been used here in combination to study the distribution and cellular localization of neuropeptides in the diffuse neuroendocrine system.
Identification of Enteramine, the Specific Hormone of the Enterochromaffin Cell System, as 5-Hydroxytryptamine
TLDR
Enteramine is the specific secretion or storage product of the typical enterochromaffin cells of the gastrointestinal mucosa of Vertebrata and Ascidia and of the chromaffin cellular elements of the posterior salivary glands of Octopoda.
Medionecrosis aortae idiopathica cystica
  • J. Erdheim
  • Medicine
    Virchows Archiv für pathologische Anatomie und Physiologie und für klinische Medizin
  • 2005
Einleitung (S. 186). I. Vorgesehichte und Leiehen6ffnung eines neuen Falles (S. 189). II . Das Bild tier Greisenaort~ (S. 190). I II . Medionecrosis idiopathiea cystiea (S. 194). 1. Kernausfall und
Über die Beziehungen zwischen dem Naevus der Haut, dem Naevus der Augenbindehaut und dem Melanom der Aderhaut
The morphological range of the cell types of the tumoral tissue in uveal melanomas does not differ from those of the naevus cell growths of the skin and the conjunctiva as shown by the examination of
...
1
2
3
4
5
...