Freshly isolated, murine neonatal T cells produce IL-4 in response to anti-CD3 stimulation.

@article{Adkins1992FreshlyIM,
  title={Freshly isolated, murine neonatal T cells produce IL-4 in response to anti-CD3 stimulation.},
  author={B D Adkins and Kelly Hamilton},
  journal={Journal of immunology},
  year={1992},
  volume={149 11},
  pages={3448-55}
}
In previous studies of chimeric animals, we found that fetal intrathymic T cell precursors give rise to phenotypically abnormal peripheral T cell populations. Because most peripheral T lymphocytes in newborn mice are the progeny of fetal T cell precursors, this result led to the hypothesis that neonatal and adult T cells differ in their functional capacities. To investigate this issue, the responses of neonatal and adult T cells to anti-CD3 antibody and TCR-independent stimulation were compared… CONTINUE READING