Fresh frozen plasma: a solution to heparin resistance during cardiopulmonary bypass.

@article{Sabbagh1984FreshFP,
  title={Fresh frozen plasma: a solution to heparin resistance during cardiopulmonary bypass.},
  author={Adib H. Sabbagh and Gregory K. W. K. Chung and Penny Shuttleworth and B J Applegate and W Gabrhel},
  journal={The Annals of thoracic surgery},
  year={1984},
  volume={37 6},
  pages={466-8}
}
The reasons for the highly variable response of patients to heparin remain incompletely understood. Empirical maintenance of the activated clotting time (ACT) at levels of 400 to 480 seconds appears to be safe for cardiopulmonary bypass (CPB). For patients with ACT responses lower than predicted for initial heparin doses, titration with additional heparin has been customary. In 44 patients undergoing cardiopulmonary bypass, 20 patients were identified as having initial ACTs of 300 seconds or… CONTINUE READING