Fresh and nonfibrillar amyloid β protein(1–40) induces rapid cellular degeneration in aged human fibroblasts: evidence for AβP‐channel‐mediated cellular toxicity

@article{Zhu2000FreshAN,
  title={Fresh and nonfibrillar amyloid β protein(1–40) induces rapid cellular degeneration in aged human fibroblasts: evidence for AβP‐channel‐mediated cellular toxicity},
  author={Y. Zhu and H. Lin and R. Lal},
  journal={The FASEB Journal},
  year={2000},
  volume={14},
  pages={1244 - 1254}
}
Alzheimer's disease (AD) is primarily nonfamilial or sporadic (SAD) in origin, although several genetic linkages are reported. Tissues from AD patients contain fibrillar plaques made of 39 to 43 amino acid‐long amyloid beta peptide (AβP), although the mechanisms of AβP toxicity are poorly understood. AβP1–40 is the most prevalent AβP present in the neuronal and non‐neuronal tissues from SAD patients. AβP1–40 toxicity has been examined mainly after prolonged incubation and correlates with the… Expand
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