Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line.

@article{GalYam2008FrequentSO,
  title={Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line.},
  author={Einav Nili Gal-Yam and Gerda Egger and Leo Iniguez and Heather L Holster and Steingrimur O Einarsson and Xinmin Zhang and Joy C. Y. Lin and Gangning Liang and Peter A. Jones and Amos Tanay},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 35},
  pages={12979-84}
}
Epigenetic reprogramming is commonly observed in cancer, and is hypothesized to involve multiple mechanisms, including DNA methylation and Polycomb repressive complexes (PRCs). Here we devise a new experimental and analytical strategy using customized high-density tiling arrays to investigate coordinated patterns of gene expression, DNA methylation, and Polycomb marks which differentiate prostate cancer cells from their normal counterparts. Three major changes in the epigenomic landscape… CONTINUE READING
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