Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2

@article{Akahoshi2011FrequentSS,
  title={Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2},
  author={Noriyuki Akahoshi and Yasuki Ishizaki and Hiroki Yasuda and Yoshiya L. Murashima and Isao Ishii},
  journal={Epilepsy & Behavior},
  year={2011},
  volume={22},
  pages={659-665}
}
The diverse physiological effects of sphingosine 1-phosphate (S1P) are mostly mediated by its five cognate G protein-coupled receptors, S1P(1)-S1P(5), which have attracted much attention as future drug targets. To gain insight into S1P(2)-mediated signaling, we analyzed frequent spontaneous seizures in S1P(2)-deficient (S1P(2)(-/-)) mice obtained after several backcrosses onto a C57BL/6N background. Full-time video recording of 120 S1P(2)(-/-) mice identified 420 seizures both day and night… CONTINUE READING
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