Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer.

@article{Park1999FrequentSM,
  title={Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer.},
  author={Won Sang Park and Ro Ra Oh and Jik Young Park and Sug Hyung Lee and Min Sun Shin and Young Sil Kim and Su Young Kim and Hee Kyu Lee and Pum Joon Kim and Seong Taek Oh and Nam Jin Yoo and Jung Young Lee},
  journal={Cancer research},
  year={1999},
  volume={59 17},
  pages={4257-60}
}
The increased level of cytoplasmic beta-catenin through the mutations to either beta-catenin or adenomatous polyposis coli (APC) has been proposed as an important oncogenic step in various tumors. Gastric cancer showed frequent genetic alterations of the APC gene, and the risk for gastric cancer in familial adenomatosus polyposis patients is 10 times higher… CONTINUE READING