Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma.

@article{Haruki2010FrequentSO,
  title={Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma.},
  author={Shigeo Haruki and Issei Imoto and Ken-ichi Kozaki and Takeshi Matsui and Hiroshi Kawachi and Shuhei Komatsu and Tomoki Muramatsu and Yutaka Shimada and Tatsuyuki Kawano and Johji Inazawa},
  journal={Carcinogenesis},
  year={2010},
  volume={31 6},
  pages={1027-36}
}
Protocadherins are a subfamily of the cadherin superfamily, but little is known about their functions. We identified a homozygous loss of protocadherin (PCDH) 17 in the course of a program to screen a panel of esophageal squamous cell carcinoma (ESCC) cell lines for genomic copy number aberrations. PCDH17 messenger RNA was expressed in normal esophageal tissue but not in the majority of ESCC cell lines without a homozygous deletion of this gene and restored in gene-silenced ESCC cells after… CONTINUE READING