Frequent replication errors at microsatellite loci in tumors of patients with multiple primary cancers.

@article{Horii1994FrequentRE,
  title={Frequent replication errors at microsatellite loci in tumors of patients with multiple primary cancers.},
  author={A Horii and H J Han and M Shimada and A Yanagisawa and Y Kato and H Ohta and W Yasui and E Tahara and Y Nakamura},
  journal={Cancer research},
  year={1994},
  volume={54 13},
  pages={3373-5}
}
  • A Horii, H J Han, +6 authors Y Nakamura
  • Published 1994 in Cancer research
Nearly 10% of cancer patients develop a second primary cancer within 10 years after surgical removal of the first tumor. Hence, detection of a genetic risk for developing multiple primary tumors would be of clinical importance. To investigate whether a genetic defect(s) involving the mismatch repair system constitutes an important risk factor in patients with multiple primary cancers, we examined replication errors (RER) at microsatellite loci in 79 primary cancers which had developed among 38… CONTINUE READING