Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesions

@article{Ang2014FrequentPM,
  title={Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesions},
  author={Daphne C. Ang and Andrea L Warrick and Amy Shilling and Carol Beadling and Christopher L . Corless and Megan L. Troxell},
  journal={Modern Pathology},
  year={2014},
  volume={27},
  pages={740-750}
}
The phosphatidylinositol-3-kinase pathway is one of the most commonly altered molecular pathways in invasive breast carcinoma, with phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) mutations in 25% of invasive carcinomas. Ductal carcinoma in situ (DCIS), benign papillomas, and small numbers of columnar cell lesions harbor an analogous spectrum of… CONTINUE READING