Frequent p16INK4a promoter hypermethylation in human papillomavirus-infected female lung cancer in Taiwan.

Inactivation of p16INK4a gene through promoter hypermethylation has been frequently observed in non small cell lung cancer; however, various studies have shown a controversial correlation between p16INK4a hypermethylation and cigarette smoking. Our recent report showed that human papillomarvirus (HPV) 16/18 infections were associated with the development of… CONTINUE READING