Frequent occurrence of identical heavy and light chain Ig rearrangements.

@article{Seidl1997FrequentOO,
  title={Frequent occurrence of identical heavy and light chain Ig rearrangements.},
  author={Katherine J. Seidl and John D. MacKenzie and Duo-chun Wang and Aaron B. Kantor and Elvin A. Kabat and Leonard A. Herzenberg},
  journal={International immunology},
  year={1997},
  volume={9 5},
  pages={
          689-702
        }
}
Single-cell PCR analyses of expressed Ig H and L chain sequences presented here show that certain rearrangements occur repeatedly and account for a major segment of the well-studied repertoire of B-1 cell autoantibodies that mediate the lysis of bromelain-treated mouse erythrocytes, i.e. antibodies reactive with phosphatldyicholine (PtC). We repeatedly isolated at least 10 different types of VH region rearrangements, involving three distinct germline genes, among FACS-sorted PtC-binding B-1… CONTINUE READING

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