Frequent occurrence of gastric cancer in Asian kindreds with Li-Fraumeni syndrome.

@article{Ariffin2015FrequentOO,
  title={Frequent occurrence of gastric cancer in Asian kindreds with Li-Fraumeni syndrome.},
  author={Hany Ariffin and Adelyne Sue Li Chan and Lixian Oh and S Abd-Ghafar and Gek Bee Ong and Mahfuzah Mohamed and Hazida Razali and Eni Juraida and S. H. Wendy Teo and Mawar Karsa and Jannah Shamsani and Pierre Hainaut},
  journal={Clinical genetics},
  year={2015},
  volume={88 5},
  pages={450-5}
}
Type of cancer and age of onset in individuals with inherited aberrations in the tumour suppressor gene TP53 are variable, possibly influenced by genetic modifiers and different environmental exposure. Since 2009, the modified Chompret criteria (MCC) have been used to identify individuals for TP53 mutation screening. Using the TP53 mutation database maintained by the International Agency for Research on Cancer (IARC), we investigated if the MCC, mainly developed for a Caucasian population, was… CONTINUE READING