Frequent occurrence of conserved extended haplotypes (CEHs) in two Caucasian populations.

@article{Szilgyi2010FrequentOO,
  title={Frequent occurrence of conserved extended haplotypes (CEHs) in two Caucasian populations.},
  author={{\'A}gnes Lilla Szil{\'a}gyi and Zsofia Banlaki and Eva Pozsonyi and Edmond J. Yunis and Zuheir L. Awdeh and Adrienn Hoss{\'o} and Katalin Rajczy and Charles E. Larsen and Dolores A. Fici and Chester A. Alper and George F{\"u}st},
  journal={Molecular immunology},
  year={2010},
  volume={47 10},
  pages={1899-904}
}
Conserved extended haplotypes (CEHs) are large (>or=1Mb) regions of identical DNA of the major histocompatibility complex (MHC) region of chromosome 6p in unrelated individuals. They are recognized by family studies and constitute nearly half of MHC haplotypes among European Caucasians. We studied 49 Hungarian Caucasian families in comparison with the previous findings in 2675 normal American Caucasian chromosomes from families in the Boston area. Besides HLA-A, -B and HLA-DRB1/-DQB1 alleles… CONTINUE READING