Frequent occurrence of Ha-rasl allelic deletion in human ovarian adenocarcinomas.

@article{Viel1991FrequentOO,
  title={Frequent occurrence of Ha-rasl allelic deletion in human ovarian adenocarcinomas.},
  author={Alessandra Viel and L De Pascale and G Toffoli and Loretta Tumiotto and Eliane Correa Miotto and Mauro Boiocchi},
  journal={Tumori},
  year={1991},
  volume={77 1},
  pages={16-20}
}
Fourteen human adenocarcinoma specimens were analyzed for somatic abnormalities affecting genes of the ras family. No amplification of the 3 ras genes was detected. Allelic deletion of the Ha-rasl gene (11p15.5) was found to be a very common abnormality in human ovarian adenocarcinomas (4 out of 7 informative cases). However, in these neoplasm deletion of a presumed normal Ha-rasl allele is not a contributory factor in strengthening the tumorigenic effect of a mutated allele. More probably, Ha… CONTINUE READING