Frequent occurrence of HIV-inhibitory sulphated polysaccharides in marine invertebrates

  title={Frequent occurrence of HIV-inhibitory sulphated polysaccharides in marine invertebrates},
  author={John A Beutler and Tawnya Carlene McKee and Richard W Fuller and Mark Tischler and John H. Cardellina and Kenneth M Snader and Thomas G. McCloud and Michael R. Boyd},
Aqueous extracts of many marine invertebrates have exhibited some activity in the National Cancer Institute's primary screen for anti-HIV cytopathicity. Using a variety of techniques, including gel permeation, size exclusion and ion exchange chromatography, toluidine blue metachromicity, 13C-NMR spectroscopy and combustion analyses, we have determined that this s activity is largely due to sulphated polysaccharides. Because of the wide occurrence of this class of compounds in these organisms we… CONTINUE READING
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