Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma.

@article{Wlodarska2003FrequentOO,
  title={Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma.},
  author={Iwona Wlodarska and Peet Nooyen and Brigitte Maes and Jos{\'e} Ignacio Mart{\'i}n-Subero and Reiner Siebert and Patrick Pauwels and Chris de Wolf-Peeters and Anne M. Hagemeijer},
  journal={Blood},
  year={2003},
  volume={101 2},
  pages={706-10}
}
We studied the genomic status of BCL6 in 23 cases of nodular lymphocyte predominance Hodgkin lymphoma (NLPHL) and 40 cases of classical Hodgkin lymphoma (cHL), using dual-color interphase fluorescence in situ hybridization (FISH). The BCL6 rearrangement was identified in 48% of NLPHL cases and was not detected in cHL cases. As a confirmation, sequential or simultaneous immunohistochemistry (IHC) and FISH using CD20 or BCL6 antibodies and BCL6 DNA probes was performed in 8 NLPHL cases. The BCL6… CONTINUE READING

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