Frequent mutation in North African patients with MUTYH-associated polyposis.

  title={Frequent mutation in North African patients with MUTYH-associated polyposis.},
  author={Jeremie H Lefevre and Chrystelle Colas and Florence Coulet and St{\'e}phanie Baert-Desurmont and C{\'e}cile Mongin and Emmanuel Tiret and Thierry 11 Fr{\'e}bourg and Florent Soubrier and Yann R Parc},
  journal={Clinical genetics},
  volume={80 4},
MUTYH-associated polyposis (MAP) has been characterized as an autosomal recessive disease predisposing to a variable number of colorectal adenomas with a high risk of cancer. Numerous studies have indicated that two missense mutations (Y179C and G396D) account for about 80% of MUTYH allelic variants in Europeans. Ethnic and geographic differences in the mutation spectrum have been observed. The aim of this study was to report mutations in patients from North Africa, determine the incidence of… CONTINUE READING